2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-127139
    Eicosapentaenoyl Chloride 98770-65-1 98%
    Eicosapentaenoyl chloride is a derivative of eicosapentaenoic acid. It has been used in the synthesis of fatty acid conjugates to enhance lipophilicity and cell permeability of bioactive compounds such as (–)-epigallocatechin gallate and salicylic acid.
    Eicosapentaenoyl Chloride
  • HY-128472
    Biotin-11-dATP 2567941-51-7 98%
    Biotin-11-dATP is a monomeric raw material that can be used for nucleic acid synthesis.
    Biotin-11-dATP
  • HY-129254
    5-Hydroxy propranolol 81907-82-6 98%
    5-Hydroxy propranolol is a metabolite of Propranolol that can be used to study β-adrenergic receptor blockade.
    5-Hydroxy propranolol
  • HY-129287
    JMV 3008 925239-09-4 98%
    JMV 3008 is a GHS-R1a antagonist with an IC50 of 5.6 nM. JMV 3008 can be used in the research of diseases such as diabetes and obesity.
    JMV 3008
  • HY-129303
    AP219 779282-36-9 99.67%
    AP39 (Item No. 17100) is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP219 is a control compound for AP39, containing the triphenylphosphonium scaffold but lacking the H2S-releasing portion.
    AP219
  • HY-129333
    L-364918 122211-31-8 98%
    L-364918 is a potent and selective oxytocin and arginine vasopressin antagonist with Ki values of 30, 1300, 2400 nM for OT, AVP-V1, AVP-V2, respectively. L-364918 has the potential for the research of preterm labor and disturbances in water balance.
    L-364918
  • HY-129516
    A-70874 131449-37-1 98%
    A-70874 is a tyrosine-free tetrapeptide analog of cholecystokinin (30-33) (CCK-4). A-70874 is an agonist that stimulates pancreatic amylase release and a partial agonist that stimulates pancreatic phosphoinositide decomposition. A-70874 has an IC50 of 4.9 nM for the guinea pig pancreatic CCK receptor. Cholecystokinin (CCK) receptors are divided into CCK-A (digestive tract) and CCK-B (brain). A-70874 has an affinity of 1.6 μM for the CCK-B/gastrin receptor.
    A-70874
  • HY-129614
    LG 82-4-01 91505-19-0 98%
    LG 82-4-01 is a thromboxane (TX) synthetase specific inhibitor, with an IC50 of 1.3 μM.
    LG 82-4-01
  • HY-129685
    M79175 82319-87-7 98%
    M79175 is an aldose reductase inhibitor that can be used in the study of early diabetic retinopathy.
    M79175
  • HY-129714
    EMD 52297 129049-51-0 98%
    EMD 52297 is a Renin inhibitor, with acute hemodynamic and hormonal effects. EMD 52297 also acts as an ACE inhibitor.
    EMD 52297
  • HY-129994
    S-Nitroso-CoA 82494-50-6 98%
    S-Nitroso-CoA (S-Nitroso-coenzyme A) is a nitrosothio compound that is coenzyme A in which the thiol group is replaced by a nitrososulfanediyl group.
    S-Nitroso-CoA
  • HY-13012R
    RepSox (Standard) 446859-33-2 98%
    RepSox (Standard) is the analytical standard of RepSox. This product is intended for research and analytical applications. RepSox (E-616452) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox can be used for the research of obesity and associated metabolic diseases such as type 2 diabetes.
    RepSox (Standard)
  • HY-130656
    8(Z)-Eicosenoic acid 76261-96-6 98%
    8(Z)-Eicosenoic acid is a cis-unsaturated free fatty acid with a 20-carbon chain. It potentiates acetylcholine (ACh) receptor channel currents without depression and enhances PCKε phosphorylation of a substrate peptide in Xenopus oocytes. 8(Z)-Eicosenoic acid constitutes 6% of the fatty acid pool in seed oil isolated from B. collina.
    8(Z)-Eicosenoic acid
  • HY-13100A
    (S)-PF 03716556 928774-44-1 98%
    (S)-PF 03716556 is a K+-competitive acid blocker with gastric acid pump inhibitory activity. (S)-PF 03716556 can be used to inhibit disease states mediated by acid pump inhibitory activity.
    (S)-PF 03716556
  • HY-131264
    Olmesartan medoxomil impurity C 879562-26-2 98.47%
    Olmesartan medoxomil impurity C (Dehydro Olmesartan medoxomil) is an uncharacterized impurity of Olmesartan medoxomil (HY-17005). Olmesartan medoxomil is a potent and selective angiotensin (angiotensin AT1) receptor inhibitor with an IC50 of 66.2 μM.
    Olmesartan medoxomil impurity C
  • HY-131310
    9(S)-HpOTrE 111004-08-1 98%
    9(S)-HpOTrE is a monohydroperoxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase (5-LO) on α-linolenic acid. It can be further metabolized to colnelenic acid by a divinyl ether synthase activity found in garlic and potato microsomal fractions. 9(S)-HpOTrE also serves as a substrate for further oxidation by both soybean and potato LOs, resulting in the formation of 9,16-dihydroperoxy acid.The suicide inactivation of LOs when 9(S)-HpOTrE is used as a substrate is thought to occur via formation of an unstable epoxide.
    9(S)-HpOTrE
  • HY-131382
    UTA1inh-C1 332144-37-3 98%
    UTA1inh-C1 is a urea transporter (UT-A) inhibitor with IC50 of 4.2 μM.
    UTA1inh-C1
  • HY-131527
    Wy-45494 hydrochloride 93413-90-2 99.65%
    Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.
    Wy-45494 hydrochloride
  • HY-131543
    22-Hydroxy mifepristone 105012-15-5 98%
    22-Hydroxy Mifepristone (RU 42698) is an orally active hydroxylated alcoholic metabolite with antiprogestational and antiglucocorticoidal activities, which contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. The relative binding affinity of 22-Hydroxy Mifepristone to the human glucocorticoid receptor is 48%.
    22-Hydroxy mifepristone
  • HY-131562
    2'-F-dUTP 66840-02-6 98%
    2'-F-dUTP (2'-Fluoro-dUTP) is a monomeric raw material that can be used for nucleic acid synthesis.
    2'-F-dUTP
Cat. No. Product Name / Synonyms Application Reactivity